Inhibition of phosphodiesterase suppresses allergic lung inflammation by regulating MCP-1 in an OVA-induced asthma murine model with co-exposure to lipopolysaccharide

Objective Asthma is a chronic inflammatory disease that can lead to severe problems with the respiratory system.This study aimed to evaluate the suppression of allergic MINERAL airway inflammation of an asthma murine model by 3-isobutyl-1-methylxanthine (IBMX), which is a non-specific cyclic nucleotide phosphodiesterase (PDE) inhibitor.Methods Alle

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Neutrophils in COVID-19

Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that neutrophils play an important role in the pathophysiology, Watch particularly in those with severe disease courses.While originally considered to be a rather homogeneous cell type, recent attention to neutrophils has uncovered their fascinating transcriptional an

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